COMBINATION OF CRIZOTINIB AND OSIMERTINIB IN T790M+ EGFR-MUTANT NON-SMALL CELL LUNG CANCER WITH EMERGING MET AMPLIFICATION POST-OSIMERTINIB PROGRESSION IN A 10-YEAR SURVIVOR: A CASE REPORT

Tyrosine kinase inhibitors (TKIs) represent the standard treatment for patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor Cafetiere (EGFR) mutations.The duration of the response is, however, limited in time owing to the development of resistance mechanisms to both first- and second-generation agents such as

Autophagy is a cellular catabolic process responsible for the degradation of cytoplasmic constituents, including organelles and long-lived proteins, that helps maintain cellular homeostasis and protect against various cellular stresses.Verteporfin is a benzoporphyrin derivative used clinically in photodynamic therapy Cafetiere to treat macular dege

Purpose: we aim is to present a learning approach for students to work on a hands-on project that may be applied to different contexts.This experience relates to an initiative to foster entrepreneurial education embedded Biscuits in economic sustainability based on the best local practices (highest-ranked municipalities) that we find and analyze to